Our findings are consistent with the observation that chemoresistant OVCA cells exhibit more extensive mitochondrial fusion than their chemosensitive counterparts [15] and induction of apoptosis in gynecologic cancer cells is associated decreased phospho-Ser637-Drp1 content and increased mitochondrial fission, both responses being attenuated by mdivi-1 [28, 29]. This evidence concerns the gene DNM1L and female reproductive organ cancer.