However, contrary to expected, we observed a reduction in the acidification of the culture medium from Raji-PCLP1 cells over time compared to Raji-Ctrl cells, as revealed by the retarded change of phenol-red pH indicator to yellow color and confirmed by pH quantification (Figure 4A, left), suggesting that PCLP1 regulates pH homeostasis in B-cell lymphoma cells. The gene discussed is PODXL; the disease is B-cell non-Hodgkin lymphoma.