RB1 and neoplasm: With multivariate analysis, >65 years of age (HR 2.41, 95% CI 1.78-3.26, p < 0.0001), high-grade tumor (HR 2.11, 95% CI 1.43-3.12, p = 0.0002) and high expression of MMP-2 (HR 1.87, 95% CI 1.08-3.26, p = 0.03), RB (HR 3.08, 95% CI 1.79-5.32, p = 0.0001) and PAI-1 (HR 2.58, 95% CI 1.52-4.38, p = 0.0004) independently predicted a worse OS (Table 5a).