Compared with the Sc-4F-treated group, in the mice treated with L-4F, the percentages of tumor-infiltrating cells producing IL-17A (1.41% vs 0.33%, P < 0.05), IL-4 (2.35% vs 0.81%, P < 0.05), IL-6 (2.99% vs 2.47%, P < 0.01), IL-1β (2.95% vs 1.34%, P < 0.01) and GM-CSF (0.96% vs 0.22%, P < 0.01) all significantly decreased, whereas the percentage of tumor-infiltrating cells producing IFN-γ (1.63%vs 1.07%, NS) did not exhibit significant changes (Figure 3A, 3B). The gene discussed is IL1B; the disease is neoplasm.