Compared with the Sc-4F-treated mice, in the mice treated with L-4F, the percentages of tumor-infiltrating Th cells producing IL-17A (19.65% vs 5.65%, P < 0.05) and IFN-γ (15.72% vs 7.7%, P < 0.05) significantly decreased, whereas the percentages of tumor-infiltrating Th cells producing IL-4 (11.11% vs 8.51%, NS), IL-6 (13.29% vs 12.53%, NS), and GM-CSF (13.84% vs 9.0%, NS) did not exhibit significant changes (Figure 4A, 4B). The gene discussed is IFNG; the disease is neoplasm.