SPARC and neoplasm: It has been reported that RUNX-2 was highly expressed in pancreatic tumor cells, PanIN lesions and tumour-associated fibroblasts/stellate cells, but showed weak to absent expression in normal pancreatic tissues and RUNX2 has the potential to regulate expression of extracellular matrix modulators SPARC and MMP1, thus influencing tumor microenvironment [6].