Recently, Melo et al. reported that glypican-1 (GPC1), a membrane-anchored proteoglycan molecule enriching circulating exosomes (GPC1+ crExos), might be useful as a non-invasive diagnostic and screening tool to detect early pancreatic cancer and to surpass conventionally used tumor markers [6]. The gene discussed is GPC1; the disease is familial pancreatic carcinoma.