CD4 and neoplasm: IL-12 will increase the production of IFN-γ, from natural killer (NK) and T cells [57], in addition to increasing the growth and cytotoxicity of activated NK cells, CD8+ and CD4+ T cells [58] and shifting differentiation of CD4+ Th0 cells toward the Th1 phenotype [59]; and enhancement of antibody-dependent cellular cytotoxicity against tumor cells [60].