COX-2 exhibits multiple biological functions and is generally thought to regulate the pathogenesis of AD via its metabolic products, including PGE2, PGD2 [and its dehydration end product 15-deoxy-∆12,14-PGJ2 (15d-PGJ2)], PGI2, PGF2α and TXA2 [46]. This evidence concerns the gene PTGS2 and Alzheimer disease.