Indeed, we observed a significant reduction of Aβ1-40 and Aβ1-42 in gmr > GULP1, APP, BACE flies as compared to gmr > APP, BACE flies (Figure 5A), indicating that GULP1 rescues structural, behavioral and longevity phenotypes in the Drosophila AD model by lowering Aβ production levels. Here, APP is linked to Alzheimer disease.