Indeed, we observed a significant reduction of Aβ1-40 and Aβ1-42 in gmr > GULP1, APP, BACE flies as compared to gmr > APP, BACE flies (Figure 5A), indicating that GULP1 rescues structural, behavioral and longevity phenotypes in the Drosophila AD model by lowering Aβ production levels. This evidence concerns the gene GULP1 and Alzheimer disease.