CCNO and Infertility: However, the constitutive loss of Ccno in our model led to apparent infertility in both males (36 pups from 2 Ccno+/+ male x female crosses; 0 pups from 3 Ccno-/- male x Ccno+/+ female crosses) and females (100 pups from 7 Ccno+/+ male x female crosses; 0 pups from 3 Ccno+/+ male x Ccno-/- female crosses).