GPT and squamous cell intraepithelial neoplasia: We also found that in both AST and ALT analysis, the SIL monotherapy group could have attained more robust therapeutic efficacy than SIL combination group (AST UI/L: MD = −8.48; 95% CI, −19.93 to 2.97, P = .15; ALT UI/L: MD = −14.31; 95% CI, −29.51 to 0.90; P = .07), so that we assume that the SIL monotherapy group exhibit improved therapeutic efficacy than combination group (as shown in Fig. 3).