In a cohort of 587 patients with CAG-confirmed CAD (318 underwent CABG and 120 received PCI), higher baseline Hcy was shown to be a strong predictor of mortality over a follow-up duration of 4.6 years.[24] Therefore, we hypothesize that interventions aimed at lowering Hcy levels in high-risk patients (such as ACS patients after PCI with T genotype of MTHFR C677T gene) may improve cardiovascular outcomes. The gene discussed is MTHFR; the disease is coronary artery disorder.