PJS first reported in the literature by Dr Connor published in 1895, and it adopted the current name in 1954 by Dr Bruwer.[7] The pathogenic gene was cloned in 1997, which is STK11 (OMIM 602216).[8] The gene encodes a 433-amino-acid-residue protein, which acts as a tumor suppressor. The gene discussed is STK11; the disease is Peutz-Jeghers syndrome.