The fact that T-cells isolated from Wiskott-Aldrich syndrome (WAS) patients show characteristic cytoskeletal defects and impaired function, highlights a direct interaction between αII spectrin and testin (Tes), a tumor suppressor [47] localized along stress fibers and participating in cell adhesion [32, 43, 48, 49]. The gene discussed is TES; the disease is Wiskott-Aldrich syndrome.