Elevated serum ferritin is independently associated with higher NAS, even among patients without hepatic iron deposition and is an independent predictor of histologic severity and advanced fibrosis in NAFLD patients.[41] The NAFLD score, calculated from the levels of ferritin, fasting insulin, and type IV collagen 7S, has been proposed for the diagnosis of NASH. The gene discussed is INS; the disease is neonatal abstinence syndrome.