Elevated serum ferritin is independently associated with higher NAS, even among patients without hepatic iron deposition and is an independent predictor of histologic severity and advanced fibrosis in NAFLD patients.[41] The NAFLD score, calculated from the levels of ferritin, fasting insulin, and type IV collagen 7S, has been proposed for the diagnosis of NASH. This evidence concerns the gene INS and metabolic dysfunction-associated steatohepatitis.