In contrast, CCR2-DTR → Irf3-/-;Irf7-/- mice treated with PBS were protected against severe RRV disease (Fig 10A and 10B), indicating that IRF3 and IRF7 sufficient hematopoietic cells can protect Irf3-/-;Irf7-/- mice against RRV-T48-nsP16M infection. The gene discussed is IRF3; the disease is infection.