A recent paper reported that HDL protects tumor-derived, immortal murine RAW264.7 and human THP-1 macrophage-like cells from apoptosis induced by treatment with etoposide or a combination of thapsigargin and fucoidan, in a manner dependent on HDL-associated S1P and cellular signal transducer and activator of transcription 3 (STAT3) and Janus Kinase 2 (JAK2) [49]. Here, MBTPS1 is linked to neoplasm.