As for IFN-γ, one study showed that low doses of SKA IFN-γ enhanced the activity of natural killer cells from patients with early-stage colon cancer [17], and another study showed that consecutive exposure to low doses of SKA IL-4 and IL-12 enhanced the immunostimulatory functions of dendritic cells from similarly afflicted patients [18]. This evidence concerns the gene IFNG and malignant colon neoplasm.