BMPR2 and heritable pulmonary arterial hypertension: Human iPSC-derived endothelial cells from three families with familial pulmonary arterial hypertension (FPAH) patients, where the autosomal dominant disease-causing BMPR2 mutation is only 20% penetrant, unaffected mutation carriers, and gender-matched controls were compared to investigate modifiers of BMPR2 signaling [120].