CXCL10 via its C-X-C motif receptor 3 (CXCR3) mediates chemotaxis of different innate immune cells47.We demonstrate that glioma infiltrating microglia express numerous chemokines and cytokines that regulate extracellular matrix, angiogenesis, chemotaxis and trafficking of different innate and regulatory immune cells, thus amplifying accumulation of myeloid cells and creating the immunosuppressive microenvironment. Here, CXCL10 is linked to glioma.