PSMB8 and Autoimmunity: Among upregulated genes we found: Anxa1 and Anxa4 coding for Annexin A1 and Annexin A4, Clec7a coding for C-type lectin domain family 7 member A which functions as a pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, Clic1 coding for chloride intracellular channel 1, Psmb8 coding for immunoproteasome subunit, β type 8 related to autoimmunity (Fig. 2B).