Upon analyzing different indices related to insulin sensitivity and secretion based on fasting levels of insulin and glucose (HOMA-R, HOMA-%B, FGIR and QUICKI), OGTT-derived indices (WBISI, ISSI-2 and IGI) and other markers of insulin resistance and glucose tolerance (TyG and HbA1c), the two Ob groups showed significantly different results for most of the parameters before and after adjusting for age, puberty and sex, but not for adjusted results for HOMA-%B, IGI and HbA1c (Table 1). The gene discussed is INS; the disease is Insulin resistance.