Intriguingly, of the 50 endocytic genes whose promoter regions are bound by Suz12 (Fig. 1b), we found that 21 genes also had seed matches for miR-294, a member of the ESCC family of miRNAs, either in their 3′UTR or ORF (Supp. This evidence concerns the gene SUZ12 and esophageal squamous cell carcinoma.