TNF and retinitis pigmentosa 1: Here, we use the RHOP347S (Rhodopsin mutant, RHOP) mouse model of RP to examine the mechanism of TrkC.T1 in the selective death of photoreceptors, the neuronal population specifically affected in this disease, and to elucidate TrkC.T1 intracellular signaling events leading to TNF-α-mediated photoreceptor death.