ARL15 and Insulin resistance: We thus sequenced coding exons and flanking sequences of ARL15 using Sanger sequencing in 189 probands with insulin resistance that was disproportionately severe to their total degree of adiposity, in a further 186 such probands using either exome sequencing (n = 62) or targeted next generation sequencing (n = 124), and 2,479 controls (Supplementary Information).