To examine the cell autonomous effect of Ezh2 on endogenous CD8+ T-cell responses, we co-transferred equal amount of WT (Thy1.1+CD45.2+) and Ezh2−/− (Thy1.1−CD45.2+) splenocytes into lymphoreplete B6/SJL mice (Thy1.1−CD45.1+), followed by infection with vaccinia virus encoding OVA (VVA-OVA). The gene discussed is CD8A; the disease is infection.