Overexpression of Ezh2S21A induced 2-fold and 4-fold more CD62Lhi CD8+ T cells in the spleen and tumor, respectively, than GFP- and Ezh2-Pmel-1 cell recipients, but did not prevent Pmel-1 cells from differentiating into CD62Llo TEFF in vivo (Fig. 7h). This evidence concerns the gene CD8A and neoplasm.