These were enriched for lymphoma-associated pathways38, 39, including PI signaling system (e.g. IMPA1, PIP5K1A, PIK3C2A, PIK3CG, PIK3R1), JAK-STAT cascade (e.g. STAT5A, STAT5B), BCR signaling (e.g. SYK, MAPK1, PIK3R1, PIK3CG, PIK3CD, RASGRP3) and MAPK signaling (e.g. MAPK1, MAPK10, MAP3K8, CACNG3) (Supplementary Table 8). The gene discussed is CACNG3; the disease is lymphoma.