These were enriched for lymphoma-associated pathways38, 39, including PI signaling system (e.g. IMPA1, PIP5K1A, PIK3C2A, PIK3CG, PIK3R1), JAK-STAT cascade (e.g. STAT5A, STAT5B), BCR signaling (e.g. SYK, MAPK1, PIK3R1, PIK3CG, PIK3CD, RASGRP3) and MAPK signaling (e.g. MAPK1, MAPK10, MAP3K8, CACNG3) (Supplementary Table 8). This evidence concerns the gene PIK3CD and lymphoma.