IGHE and Increased total eosinophil count: Immune-activated over-expression of IL-4, -5, -10, -13, and TGF-β1 drives eosinophilia and increased IgG4 and IgE levels in IgG4-RD, thus this suggests that at states of increased disease activity, Th1, Th2, Treg, and eosinophil involvement would be greater6.