INS and obesity due to melanocortin 4 receptor deficiency: Such low‐grade inflammation has been repeatedly linked to obesity, increased insulin resistance, and diabetes (Gregor & Hotamisligil, 2011) providing a potential explanation for our observation that BMI and insulin resistance are significantly higher in individuals who predominantly harbor the flagellum‐carrying subspecies (MGSS2 and MGSS3) in the Danish (Le Chatelier et al, 2013) and Swedish (Karlsson et al, 2013) cohorts (Fig 3D).