The genes with MXEs carrying pathogenic SNPs are predominantly associated with neurological disease (10), neuromuscular disorders (7), cardiomyopathies (6) and cancer (3) and are enriched in voltage‐gated cation channels (e.g. CACNA1C and CACNA1D), muscle contractile fibre genes (e.g. TPM1), and transmembrane receptors (e.g. FGFR1‐3; Fig 4, Appendix Fig S27, Dataset EV7). Here, TPM1 is linked to cardiomyopathy.