As discussed previously, AMPK may play an important role in inducing the oxidative myogenic program, and observations from several animal studies in which mdx mice have been treated with AMPK activating compounds such as AICAR, metformin, and resveratrol suggest that targeting AMPK in skeletal muscle may ameliorate the pathology observed in patients with DMD (12, 463, 464). Here, PRKAA2 is linked to Duchenne muscular dystrophy.