PGR and neoplasm: Within trials, response was more common in women with small, ER-negative and progesterone receptor-negative, or high-grade tumours, as measured before randomisation, but was little affected by age, nodal status, or planned local therapy.8, 9, 10, 11, 12, 13, 14, 15, 16, 17 As expected, use of NACT was associated with an increase in the use of breast-conserving therapy.