These results not only verify that Rab14 acts as a LYST antagonist in human cells, as in Dictyostelium species,55 but also confirm that cell activation and lytic granule functionality are normal in NK cells from patients with CHS, and the limited area of actin clearances at the immunologic synapse accessible for the large granules in LYST-deficient NK cells restricts their release. This evidence concerns the gene LYST and Chédiak-Higashi syndrome.