Although IQGAP1 is proposed to have various functions in progression of cancers [18], oncogenic potential in canine melanoma [19], and chemotherapeutic drug resistance in human melanoma patients [20], nothing is known of the domains needed for cell retraction localization and little is known of IQGAP1 function in the melanoma cell cytoskeleton. The gene discussed is IQGAP1; the disease is melanoma.