NFKB1 and acute myeloid leukemia: Previously, we and others identified that AML cells frequently display constitutive NF-kB activity [37,49,50] and heavily depend on TAK1 for their survival [35], and here we show that FLT3-ligand stimulated MLL-AF9 cells also do not tolerate inhibition of either TAK1 of NF-kB activity.