Affymetrix LCM dataset analysis on uterine endometrial cancers and uterine serous cancers showed an elevated cancer/normal expression ratio with biosynthetic enzymes such ODC1, spermidine synthase (SRM) and spermine synthase (SMS), while the ratio of catabolic enzymes like SAT1, polyamine oxidase (PAOX) and spermine oxidase (SMOX) showed no difference in expression (S2 Fig). The gene discussed is SMS; the disease is endometrial cancer.