More specifically, by using a microfluidic-based single-cell GPCR expression analysis in both primary smooth muscle cells (SMCs) and endothelial cells (ECs), the authors demonstrated that although the GPCR expression is heterogeneous in normal conditions, several subpopulations expressing specific GPCRs patterns can be detected upon stressful stimuli, such as inflammation, sepsis or atherosclerosis [97]. Here, FZD4 is linked to Sepsis.