AKT1 and cancer: As it concerns the molecular mechanisms of action, estrogenic GPER signaling engages several rapid transduction cascades such as MAPKs and PI3K/AKT, which in turn activate the intracellular transcriptional machinery, leading to stimulatory effects in cancer cells, as well as in components of the tumor microenvironment such as Cancer Associated Fibroblasts (CAFs) [200,201].