LPAR1 and plasma cell myeloma: Additionally, both LPAR1 and LPAR3 have been implicated in multiple myeloma vascularization [134], while LPAR1 has been shown to boost angiogenic response in pre-neoplastic lesions, thus suggesting that the involvement of these receptors in the transition from dysplastic to neoplastic formations is correlated with increased angiogenesis [135].