SIRT2 and neoplasm: This is not unexpected because SIRT2 is known to exert tumor-promoting functions by deacetylating various targets (He et al., 2012; Hu et al., 2014; Jing et al., 2016; Jing and Lin, 2015; Liu et al., 2013; Wang et al., 2014; Xu et al., 2016; Zhao et al., 2013; Zhou et al., 2016).