Given that Ras proteins play critical roles in many human cancers, SIRT2, as a Ras regulator, may be an important therapeutic target for cancer, which is consistent with several recent reports (Jing et al., 2016; Moniot et al., 2017; Shah et al., 2016; Wang et al., 2014; Wilking-Busch et al., 2017; Xu et al., 2016; Zhao et al., 2013, 2016). This evidence concerns the gene SIRT2 and cancer.