79 (87.8%) of 90 normal mucosa and 57 (63%) of 90 GC specimens exhibited high SMG‐1 expression levels (Table 1, P = 0.0002),and IHC signals in GC tissues were significantly lower than in normal tissues (Fig. 2A; paired t‐test, P = 0.0004). This evidence concerns the gene SMG1 and gastric cancer.