Meanwhile, multivariate Cox analysis further revealed that SERPINH1 was a potential independent prognostic marker for DFS in patients with VHL‐WT ccRCC (Low versus High; Univariate and Multivariate; HR = 0.230 and 0.362, 95% CI: 0.129–0.411 and 0.195–0.672, P < 0.001 and 0.01, respectively Fig. S10). Here, SERPINH1 is linked to nonpapillary renal cell carcinoma.