The fact that the prevalence of IGF2 LOI was similar in tumors and normal prostate and that the IGF2 imprinting status was often concordant in T and N supports the previous view that IGF2 LOI is an early event in the development of PCa and indicates an epigenetic field defect in the adjacent ‘normal’ prostatic tissue (Bhusari et al., 2011). The gene discussed is IGF2; the disease is posterior cortical atrophy.