In colon cancer cells, the polycomb‐repressive complex 2 docking factor SUZ12 has been proposed to regulate imprinting by binding to the IGF2 promoter, connecting CTCF and the ICR over a long range intrachromosomal loop with IGF2. Vigilin has also been shown to build a complex with CTCF that binds to the ICR of H19 and contributes to IGF2/miR‐675/H19 regulation. Here, IGF2 is linked to colonic neoplasm.