IGF2 and esophageal adenocarcinoma: Loss of imprinting is believed to result from ICR hypermethylation of both alleles and bi‐allelic transcription of IGF2. A good correlation between LOI and increased IGF2 expression in tumors and preneoplastic lesions has been shown for many tumors, including Wilms tumor, colorectal cancer, and esophageal adenocarcinomas (Belharazem et al., 2016; Hubertus et al., 2011; Mori et al., 1996; Nakagawa et al., 2001).