Eight of the patients (10%) reported symptoms suggestive of an underlying connective tissue disorder, including Raynaud (n = 6), mild arthralgia (n = 3), and/or myalgia (n = 2), and 10 patients (13%) had positive antinuclear antibodies (ANA > 1/160); yet, the rest specific circulating auto-antibodies (extractable nuclear antigen-ENA panel, rheumatoid factor, cyclic citrullinated peptides-CCPs) were negative. Here, BTG3 is linked to connective tissue disorder.