TNF and rheumatoid arthritis: In accordance with the histologic and immunochemical results, QWRG (2.0 and 4.0 g/kg) can significantly alleviate the inflammation of the synovial cavity in RA rats and reduce the grading of synovitis through inhibiting the expressions of IL-1β, TNF-α, and IL-16 in the serum and synovium of RA rats.