The AMLprofiler (SkylineDx, Rotterdam, The Netherlands) is a qualitative in vitro diagnostic microarray that uses RNA chemistry to identify seven key molecular biomarkers used for the diagnosis and prognosis of AML: inv(16)/t(16;16), t(8;21), and t(15;17); biallelic CEBPA mutation (CEBPAdm); ABD-type NPM1 mutations; BAALC-low and EVI1-high mRNA expression levels. The gene discussed is NPM1; the disease is acute myeloid leukemia.