Consistent with the results pointing to a detrimental role of specific risk genotypes for IPA regarding cytokine production, we observed that the high-risk GG genotype at rs2305619 in PTX3 led to a decrease of 23% sensitivity for IL-8 and 29% specificity for IL-6, hindering their performance in identifying cases (AUCROC = 0.67; 95% CI, 0.33–0.97; P = 0.70) and controls (AUCROC = 0.58; 95% CI, 0.22–0.89; P = 0.80), respectively (Table S3). The gene discussed is CXCL8; the disease is Ito hypomelanosis.