VEGFA and Alzheimer disease: As a compensatory response to injury, up-regulation of VEGF occurs in stroke, traumatic injury, aneurysms, and AD and could be directly related to disease pathogenesis (Skirgaudas et al., 1996; Kalaria et al., 1998; Shore et al., 2004; Storkebaum et al., 2004; Merrill and Oldfield, 2005).