However, the present study showed a significant increase in the expression of AQP4 in the brains of APP/PS1 mice, which is in accordance with some human and animal studies (Hoshi et al., 2012; Xu et al., 2015).The above inconsistent results in AQP4 expression in AD may be associated with the different stages of disease, specific neuroanatomical areas, and whether patients had complications or not. Here, APP is linked to Alzheimer disease.