The modulation of c-MET pathway activity by TGF-β allows to speculate that subsets of patients with glioblastoma would have responded to TGF-β inhibitors such as galunisertib (LY2157299 monohydrate) with an increase of c-MET activity and potentially MET-mediated migration and invasion. Here, TGFB1 is linked to glioblastoma.