This assumption was confirmed by a negative correlation between TGF-β2 and p-c-MET immunoreactivity upon double immunostaining in a large cohort of glioblastoma patients (Fig. 5) as well as by a negative correlation between TGF-β1 and HGF gene expression at single-cell level in freshly resected glioblastoma tissues (Fig. 6a). This evidence concerns the gene MET and glioblastoma.