In a therapeutic experiment using the HeLa-RIPK3 D2 clone, RIPK3 expression significantly enhanced the activity of intratumoural dl922-947 (Fig. 5e, Fig. S11), with complete elimination of 3/6 HeLa-RIPK3 D2 tumours compared to 0/6 HeLa-LZRS tumours. Here, RIPK3 is linked to neoplasm.