Although no effect of BCL-XL overexpression on HIF-1/VEGF pathway was observed under the normoxic condition, interestingly we found that under hypoxia, BCL-XL overexpressing melanoma cells showed a higher level of the α subunit of transcription factor HIF-1 respect to control transfectants grown under the same condition (Supplementary Fig. S8). The gene discussed is HIF1A; the disease is melanoma.