It has been reported that the V2 loop of HIV-1 gp120 binds to the integrin α4β7 expressed on activated CD4+ T cells, mediating viral uptake and infection (29, 37), which could be abrogated by anti-V1V2 antibodies, although this may not be applicable for all HIV-1 strains (38). The gene discussed is ITIH4; the disease is infection.